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名古屋大学大学院 理学研究科 生命理学専攻
遺伝学グループ
発表論文
Preprint
Hinata C, Nakagawa H, Nonaka S, Nozaki K, Sato Y, *Ohsawa S
Extrinsic MMPs drive epithelial shape change via basal ECM disassembly in the Drosophila wing disc
bioRxiv 2026 Jan 21
2025年
Hirooka E, Hattori R, Ikawa K, Kobayashi T, Matsuyama M, Igaki T, *Ohsawa S
Macrophages promote tumor growth by phagocytosis-mediated cytokine amplification in Drosophila
Curr. Biol., 35, 3209-3227 (2025) doi: 10.1016/j.cub.2025.05.068
Enomoto M, *Ohsawa S
Cancer progression through systemic signaling viewed from Drosophila
Curr. Opin. Cell Biol., 95, 102545 (2025) doi: 10.1016/j.ceb.2025.102545
Akai N, Yagi Y, Igaki T, *Ohsawa S
JNK signaling coordinates epithelial cell turnover through exocytosis in Drosophila ribosomal protein mutants
iScience, 28, 112587 (2025) doi: 10.1016/j.isci.2025.112587.
Li J, Taniguchi K, Ye W, Kondo S, Kobayashi T, Matsuyama M, Saito K, Ohsawa S, Igaki T
Epithelial cell-fate switch triggering ectopic ligand-receptor-mediated JAK-STAT signaling promotes tumorigenesis in Drosophila
iScience, 28, 112191 (2025)
〜2025年
Ikawa K, Hiro S, Kondo S, Ohsawa S, Sugimura K
Coronin-1 promotes directional cell rearrangement in Drosophila wing epithelium
Cell Struct Funct, 48, 251-257 (2023)
Nagata R, Akai N, Kondo S, Saito K, Ohsawa S, Igaki T
Yorki drives supercompetion by non-autonomous induction of autophagy via bantam microRNA in Drosophila
Current Biology, 32, 1064-1076 (2022)
Cong B, Nakamura M, Sando Y, Kondo T, Ohsawa S, Igaki T
JNK and Yorkie drive tumor malignancy by inducing L-amino acid transporter 1 in Drosophila
PLoS Genetics, 17, e1009893 (2021)
Wada Y, Ohsawa S, Igaki T
Yorkie ensures robust tissue growth in Drosophila ribosomal protein mutants
Development, 148, dev198705 (2021)
#Akai N, #*Ohsawa S(# Equal Contribution; *Co-Corresponding Author), Sando Y, *Igaki T
Epithelial cell-turnover ensures robust coordination of tissue growth in Drosophila ribosomal protein mutants
PLoS Genetics, 17, e1009300 (2021)
Iida C, Ohsawa S, Taniguchi K, Yamamoto M, Morata G, Igaki T
JNK-mediated Slit-Robo signaling facilitates epithelial wound repair by extruding dying cells
Sci. Rep., 9, 19549 (2019)
Ohsawa S
Elimination of oncogenic cells that regulate epithelial homeostasis in Drosophila
Dev. Growth. Differ., 61, 337-342 (2019) (Invited Review)
Tsuboi A,Ohsawa S, Umetsu D, Sando Y, Kuranaga E. Igaki T, Fujimoto K
Competition for Space Is Controlled by Apoptosis-Induced Change of Local Epithelial Topology
Curr. Biol., 28, 2115-2128 (2018)
Katsukawa M, Ohsawa S, Zhang L, Yan Y, Igaki T
Serpin Facilitates Tumor-Suppressive Cell Competition by Blocking Toll-Mediated Yki Activation in Drosophila
Curr. Biol., 28, 1756-1767 (2018)
Akai N, *Igaki T, *Ohsawa S(*co-corresponding author)
Wingless signaling regulates winner/loser status in Minute cell competition
Genes Cells, 23, 234-240 (2018)
#Ohsawa S, #Vaughen J (#equal contribution), Igaki T
Cell Extrusion: A Stress-Responsive Force for Good or Evil in Epithelial Homeostasis
Dev. Cell, 44, 284-296 (2018)(Invited Review)
Cong B, Ohsawa S, Igaki T
JNK and Yorkie drive tumor progression by generating polyploid giant cells in Drosophila
Oncogene, 37, 3088-3097 (2018)
#Yamamoto M, #Ohsawa S (#equal contribution), Kunimasa K, Igaki T
The ligand Sas and its receptor PTP10D drive tumour-suppressive cell competition
Nature, 542, 246-250 (2017)
Nishikawa S, Takamatsu A, Ohsawa S, Igaki T
Mathematical model for cell competition: Predator-prey interactions at the interface between two groups of cells in monolayer tissue
J. Theoretical Biology, 404, 40-50 (2016)
Enomoto M, Kizawa D, Ohsawa S, Igaki T
JNK signaling is converted from anti- to pro-tumor pathway by Ras-mediated switch of Warts activity
Dev. Biol., 403, 162-171 (2015)
#Takino K, #Ohsawa S (#equal contribution), Igaki T
Loss of Rab5 drives non-autonomous cell proliferation through TNF and Ras signaling in Drosophila
Dev. Biol., 395, 19-28 (2014)
#Nakamura M, #Ohsawa S (#equal contribution), Igaki T
Mitochondrial defects trigger proliferation of neighboring cells via senescence-associated secretory phenotype in Drosophila
Nature Communications, 5, 5264 (2014)
Ohsawa S, Takemoto D, Igaki T
Dissecting tumor heterogeneity in flies: genetic basis of interclonal oncogenic cooperation
J. Biochem., 156 129-136 (2014) (Invited Review)
Ohsawa S, Sato Y, Enomoto M, Nakamura M, Betsumiya A, Igaki T
Mitochondrial defect drives non-autonomous tumour progression via Hippo signalling in Drosophila
Nature, 490, 547-551 (2012)
Ohsawa S, Sugimira K, Takino K, Igaki T:
Imaging cell competition in Drosophilaimaginal discs.
Methods in Enzymology, 506 407-413 (2012) (Invited Review)
#Ohsawa S, Sugimura K, Takino K, Xu T, Miyawaki A, Igaki T
Elimination of oncogenic neighbors by JNK-mediated engulfment in Drosophila
Dev. Cell, 20, 315-328 (2011)
Ohsawa S, Hamada, S, Kuida K, Yoshida H, Igaki T, Miura M:
Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity.
Proc. Natl. Acad. Sci. USA.,107, 13366-13371 (2010)
Ohsawa S, Hamada, S, Asou H, Kuida K, Uchiyama Y, Yoshida H, Miura M
Caspase-9 activation revealed by Semaphorin 7A cleavage is independent of apoptosis in the aged olfactory bulb.
J. Neurosci., 29 11385-11392 (2009)
Ohsawa S,Hamada S, Yoshida H, Miura M
Caspase-mediated changes in Histone H1 in early apoptosis: prolonged caspase activation in developing olfactory sensory neurons.
Cell Death Differ., 15 1429-1439 (2008)
Ohsawa S, Watanabe T, Katada T, Nishina H, Miura M
Novel antibody to human BASP1 labels apoptotic cells post-caspase activation.
Biochem. Biophys. Res. Commun., 371 639-643 (2008)
Ohsawa S, Miura M
Caspase-mediated changes in Sir2a during apoptosis.
FEBS Lett., 580 5875-5879 (2006)
Ohsawa S, Hamada S, Kakinuma Y, Yagi T, Miura M
A novel function of neuronal PAS domain protein 1 (NPAS1) in Erythropoietin expression in neuronal cells.
J. Neurosci. Res., 79 451-458 (2005)
Kakinuma Y, Saitoh F, Ohsawa S, Furuichi T, Miura M:
A sulfatase regulating the migratory potency of oligodendrocyte progenitor cells through tyrosine phosphorylation of b-catenin.
J. Neurosci. Res., 77 653-661 (2004)
Kikuchi Y, Ohsawa S, Mimura J, Ema M, Takasaki C, Sogawa K, Fujii-Kuriyama Y:
Heterodimers of bHLH-PAS protein fragments derived from AhR, AhRR, and Arnt prepared by co-expression in Escherichia coli: characterization of their DNA binding activity and preparation of a DNA complex.
J. Biochem., 134 83-90 (2003)
和文総説
大澤 志津江
がん原性変異細胞と正常細胞との間で引き起こされるがん抑制型細胞競合（ショウジョウバエをモデルとして）
医学のあゆみ第１土曜特集「細胞競合による生体制御とがん」Vol.247, No.5 413-419 (2020)