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発表論文

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Nagata R, Akai N, Kondo S, Saito K, Ohsawa S and Igaki T

Yorki drives supercompetion by non-autonomous induction of autophagy via bantam microRNA in Drosophila

Current Biology, 32, 1064-1076 (2022)

Cong B, Nakamura M, Sando Y, Kondo T, Ohsawa S and Igaki T

JNK and Yorkie drive tumor malignancy by inducing L-amino acid transporter 1 in Drosophila

PLoS Genetics, 17, e1009893  (2021)

Wada Y, Ohsawa S, Igaki T

Epithelial cell-turnover ensures robust coordination of tissue growth in Drosophila ribosomal protein mutants

Development, 148, dev198705 (2021)

#Akai N, #*Ohsawa S(# Equal Contribution; *Co-Corresponding Author), Sando Y, *Igaki T

Yorkie ensures robust tissue growth in Drosophila ribosomal protein mutants

PLoS Genetics, 17, e1009300 (2021)

Iida C, Ohsawa S, Taniguchi K, Yamamoto M, Morata G, Igaki T

JNK-mediated Slit-Robo signaling facilitates epithelial wound repair by extruding dying cells

Sci. Rep., 9, 19549 (2019)

Ohsawa S

Elimination of oncogenic cells that regulate epithelial homeostasis in Drosophila

Dev. Growth. Differ., 61, 337-342 (2019) (Invited Review)

Tsuboi A,Ohsawa S, Umetsu D, Sando Y, Kuranaga E. Igaki T, Fujimoto K

 Competition for Space Is Controlled by Apoptosis-Induced Change of Local Epithelial Topology

 Curr. Biol., 28, 2115-2128 (2018)

Katsukawa M, Ohsawa S, Zhang L, Yan Y, Igaki T

Serpin Facilitates Tumor-Suppressive Cell Competition by Blocking Toll-Mediated Yki Activation in Drosophila

 Curr. Biol., 28, 1756-1767 (2018)

Akai N, *Igaki T, *Ohsawa S(*co-corresponding author)

 Wingless signaling regulates winner/loser status in Minute cell competition

Genes Cells, 23, 234-240 (2018)

#Ohsawa S, #Vaughen J (#equal contribution), Igaki T

Cell Extrusion: A Stress-Responsive Force for Good or Evil in Epithelial Homeostasis

Dev. Cell, 44, 284-296 (2018)(Invited Review)

Cong B, Ohsawa S, Igaki T

 JNK and Yorkie drive tumor progression by generating polyploid giant cells in Drosophila  

 Oncogene, 37, 3088-3097 (2018)

#Yamamoto M, #Ohsawa S (#equal contribution), Kunimasa K, Igaki T

The ligand Sas and its receptor PTP10D drive tumour-suppressive cell competition

 Nature, 542, 246-250 (2017)

Nishikawa S, Takamatsu A, Ohsawa S, Igaki T

Mathematical model for cell competition: Predator-prey interactions at the interface between two groups of cells in monolayer tissue  

J. Theoretical Biology, 404, 40-50 (2016)

Enomoto M, Kizawa D, Ohsawa S, Igaki T

JNK signaling is converted from anti- to pro-tumor pathway by Ras-mediated switch of Warts activity  

Dev. Biol., 403, 162-171 (2015)

#Takino K, #Ohsawa S (#equal contribution), Igaki T

Loss of Rab5 drives non-autonomous cell proliferation through TNF and Ras signaling in Drosophila

Dev. Biol., 395, 19-28 (2014)

#Nakamura M, #Ohsawa S (#equal contribution), Igaki T

Mitochondrial defects trigger proliferation of neighboring cells via senescence-associated secretory phenotype in Drosophila  

Nature Communications, 5, 5264 (2014)

Ohsawa S, Takemoto D, Igaki T

Dissecting tumor heterogeneity in flies: genetic basis of interclonal oncogenic cooperation  

J. Biochem., 156 129-136 (2014) (Invited Review)

Ohsawa S, Sato Y, Enomoto M, Nakamura M, Betsumiya A, Igaki T

Mitochondrial defect drives non-autonomous tumour progression via Hippo signalling in Drosophila  

Nature, 490, 547-551 (2012)

Ohsawa S, Sugimira K, Takino K, Igaki T: 

 Imaging cell competition in Drosophilaimaginal discs.  

 Methods in Enzymology, 506 407-413 (2012) (Invited Review)

#Ohsawa S, Sugimura K, Takino K, Xu T, Miyawaki A, Igaki T

Elimination of oncogenic neighbors by JNK-mediated engulfment in Drosophila

Dev. Cell, 20, 315-328 (2011)

Ohsawa S, Hamada, S, Kuida K, Yoshida H, Igaki T, Miura M: 

 Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity.

 Proc. Natl. Acad. Sci. USA.,107, 13366-13371 (2010)

Ohsawa S, Hamada, S, Asou H, Kuida K, Uchiyama Y, Yoshida H, Miura M

Caspase-9 activation revealed by Semaphorin 7A cleavage is independent of apoptosis in the  aged olfactory bulb.

J. Neurosci., 29 11385-11392 (2009)

Ohsawa S,Hamada S, Yoshida H, Miura M

Caspase-mediated changes in Histone H1 in early apoptosis: prolonged caspase activation in developing olfactory sensory neurons.

Cell Death Differ., 15 1429-1439 (2008)

Ohsawa S, Watanabe T, Katada T, Nishina H, Miura M

 Novel antibody to human BASP1 labels apoptotic cells post-caspase activation.

Biochem. Biophys. Res. Commun., 371 639-643 (2008)

Ohsawa S, Miura M

 Caspase-mediated changes in Sir2a during apoptosis.

 FEBS Lett., 580 5875-5879 (2006)

Ohsawa S, Hamada S, Kakinuma Y, Yagi T, Miura M

 A novel function of neuronal PAS domain protein 1 (NPAS1) in Erythropoietin expression in neuronal cells.  

J. Neurosci. Res., 79 451-458 (2005)

Kakinuma Y, Saitoh F, Ohsawa S, Furuichi T, Miura M:

A sulfatase regulating the migratory potency of oligodendrocyte progenitor cells through  tyrosine phosphorylation of  b-catenin.

J. Neurosci. Res., 77 653-661 (2004)

Kikuchi Y, Ohsawa S, Mimura J, Ema M, Takasaki C, Sogawa K, Fujii-Kuriyama Y: 

Heterodimers of bHLH-PAS protein fragments derived from AhR, AhRR, and Arnt prepared by co-expression in Escherichia coli: characterization of their DNA binding activity and  preparation of a DNA complex.

J. Biochem., 134 83-90 (2003)

（４）

和文総説

大澤 志津江

がん原性変異細胞と正常細胞との間で引き起こされるがん抑制型細胞競合（ショウジョウバエをモデルとして）

医学のあゆみ第１土曜特集「細胞競合による生体制御とがん」Vol.247, No.5 413-419 (2020)

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